Sickle Cell

garner toss off cubicle Anemia We feel that this floor looks a serve up better single-spaced. A truncated History of Sickle booth illness Sickle prison cell Disease in African Tradition Sickle cellular telephone malady has been know to the peoples of Africa for hund ruby-reds, and maybe thousands, of years. In westmost Africa various ethnic groups gave the condition unlike names: Ga category: Chwechweechwe Faute tribe: Nwiiwii Ewe tribe: Nuidudui Twi tribe: Ahotutuo Sickle Cell Disease in the Western literary productions Description of Sickle Cell Disease In the western literature, the graduation description of reap hook cell disease was by a moolah physician, James B. Herrick, who noted in 1910 that a patient of his from the West Indies had an anemia characterized by unusual red cells that were reap hook shaped. Relationship of Red Cell Sickling to atomic exit 8 In 1927, Hahn and Gillespie showed that sickling of the red cells was related to low oxygen. Deoxygenation and haemoglobin In 1940, Sherman (a medical student at Johns Hopkins) noted a double refraction of deoxygenated red cells, suggesting that low oxygen modify the structure of the haemoglobin in the molecule.

Protective Role of fetal hemoglobin in Sickle Cell Disease Janet Watson, a pediatric hematolist in New York, suggested in 1948 that the paucity of sickle cells in the off-base blood of spick-and-spanborns was due to the presence of fetal hemoglobin in the red cells, which consequently did not harbor the abnormal sickle hemoglobin seen in adults. Abnormal Hemoglobin in Sickle Cell Disease Using the new technique of protein electrophoresis, Linus Pauling and colleagues showed in 1949! that the hemoglobin from patients with sickle cell disease is different than that of normals. This make sickle cell disease the first disorder in which an abnormality in a protein was known to be at fault. Amino Acid Substitution in Sickle Hemoglobin In 1956, Vernon Ingram, then at the MRC in England, and J.A. Hunt sequenced sickle hemoglobin and showed that a glutamic acid at...If you indigence to get a full essay, order it on our website: OrderEssay.net

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